[Purpose/significance] Intermediary Websites for open innovation are dynamic and open mediation patterns of innovation, connecting widely with different innovation participants, including enterprises, universities, research institutions and the public, and having great significance to scientific research in the new era. [Method/process] The attributes of intermediary Websites for open innovation have been summarized. The mediation mechanism and its implementation of intermediary Websites for open innovation have been analyzed. This paper takes InnoCentive as one typical case. [Result/conclusion]Intermediary Websites for open innovation help establish an effective link between enterprises and academic institutions, bringing many inspirations on scientific research. Academic institutions should conduct scientific innovations with more open ideas, and can use intermediary Websites for open innovation to choose research subjects, to construct industry–university relationship, to transfer research outputs, as well as to stimulate creative ideas.