[Purpose/Significance] The new era shows distinctive knowledge-based features. Enterprise innovation is the cornerstone of high-quality development, this paper aims to analyze the opportunities and challenges of human resource management in the new era, analyze hard and soft knowledge and their roles in terms of enterprise’s R&D and management innovation from the perspective of all-around innovation, and build a pagoda structure of enterprise innovators and innovation results. [Method/Process] Concerning the whole process of R&D in the enterprise of "research, design and development, processing and manufacturing", the innovation potential of front-line employees and their value, role, and contribution were analyzed from the perspective of soft knowledge, and then a knowledge-based human resource management structure was proposed. [Result/Conclusion] This study serves to enhance the knowledge-based level of enterprise innovation, make the foundation of the innovation pagoda structure stronger and more stable, solve and alleviate the front-line paradox, and realize the high-quality development of the last kilometer of enterprise research and development.