[Purpose/Significance] Open Science, as a revolutionary system engineering, is faced up with many challenges in its evolution, for which it needs to break through the limitations of multiple barriers between nations, expertise, narrow interests, and among others. [Method/Process] China had made continuous efforts in innovating the scientific-research incentive system, creating an open scientific environment, and strengthening organizational and platform construction support. In the process of accelerating the full implementation of the values of open science, namely "freedom, openness, cooperation and sharing", and continuously deepening the all-round cooperation with international organizations including UNESCO by establishing and operating Category II centers, through which it had accumulated experience in cooperating with international organizations to promote the development open science. [Result/Conclusion] Its successful practice proves the effectiveness of open science as a non-market incentive mechanism for scientific and technological development and innovation, reflects the unique advantages of UNESCO in leading the development of open science, and facilitates to create a positive oriented global cooperation model for the development of open science by the participation of international organizations. The summary of its experience will help guide China to give better play to China's overall institutional advantages within the mechanism framework of "1 + 1 > 2" in the future, realizing "to win the race by overtaking on a bend" in the process of solving problems and tapping potentials, so as to open up a new path of open and scientific development with Chinese characteristics.