[目的/意义] 开放科学作为一个革命性的系统工程，其发展过程中面临着一系列挑战，需要突破国家间、专业性与狭隘利益等多重壁垒的局限。[方法/过程] 中国在创新科研激励体制、营造开放科学环境、加强组织支持与平台建设支持等方面持续发力，加速开放科学“自由、开放、合作、共享”理念的全面落地的过程中，也通过建立与运营二类中心的方式，不断深化着与UNESCO在内的国际组织的全方位合作机制，积累着与国际组织合作助推开放科学发展的经验。[结果/结论] 其成功实践，证明开放科学作为一种非市场性科技发展与创新激励机制的有效性，体现出UNESCO在引领开放科学发展方面所具有的独特优势，并使得国际组织参与的开放科学发展开创出一种积极导向的全球化合作模式。对其经验的总结，有利于引导中国在未来“1+1＞2”的机制框架内更好发挥中国的总体制度优势，并在解决问题、激发潜力的过程中实现“弯道超车”，开辟出中国特色的开放科学发展新路。

[Purpose/Significance] Open Science, as a revolutionary system engineering, is faced up with many challenges in its evolution, for which it needs to break through the limitations of multiple barriers between nations, expertise, narrow interests, and among others. [Method/Process] China had made continuous efforts in innovating the scientific-research incentive system, creating an open scientific environment, and strengthening organizational and platform construction support. In the process of accelerating the full implementation of the values of open science, namely "freedom, openness, cooperation and sharing", and continuously deepening the all-round cooperation with international organizations including UNESCO by establishing and operating Category II centers, through which it had accumulated experience in cooperating with international organizations to promote the development open science. [Result/Conclusion] Its successful practice proves the effectiveness of open science as a non-market incentive mechanism for scientific and technological development and innovation, reflects the unique advantages of UNESCO in leading the development of open science, and facilitates to create a positive oriented global cooperation model for the development of open science by the participation of international organizations. The summary of its experience will help guide China to give better play to China's overall institutional advantages within the mechanism framework of "1 + 1 > 2" in the future, realizing "to win the race by overtaking on a bend" in the process of solving problems and tapping potentials, so as to open up a new path of open and scientific development with Chinese characteristics.